Oxaliplatin is contra-indicated in patients who: have a known history of hypersensitivity to oxaliplatin; are breast feeding; have myelosuppression prior to starting first course, as evidenced by baseline neutrophils; <2 x 109/l and/or platelet count of < 100 x 109/l; have a peripheral sensitive neuropathy with functional impairment prior to first course; have a severely impaired renal function (creatinine clearance less than 30ml/min).